<?xml version="1.0" encoding="UTF-8"?> <!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.2d1 20170631//EN" "JATS-journalpublishing1.dtd"> <ArticleSet> <Article> <Journal> <PublisherName>aaspjournal</PublisherName> <JournalTitle>Journal of Asian Association of Schools of Pharmacy</JournalTitle> <PISSN>I</PISSN> <EISSN>S</EISSN> <Volume-Issue>Volume 1 No.1</Volume-Issue> <PartNumber/> <IssueTopic>Multidisciplinary</IssueTopic> <IssueLanguage>English</IssueLanguage> <Season>January - March, 2012</Season> <SpecialIssue>N</SpecialIssue> <SupplementaryIssue>N</SupplementaryIssue> <IssueOA>Y</IssueOA> <PubDate> <Year>-0001</Year> <Month>11</Month> <Day>30</Day> </PubDate> <ArticleType>Pharmacy</ArticleType> <ArticleTitle>Effect of melatonin co-treatment against kainic acid on thiol redox modulator gene expressions in Rat Hippocampus</ArticleTitle> <SubTitle/> <ArticleLanguage>English</ArticleLanguage> <ArticleOA>Y</ArticleOA> <FirstPage>38</FirstPage> <LastPage>46</LastPage> <AuthorList> <Author> <FirstName>Guliz</FirstName> <LastName>Armagan</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>N</CorrespondingAuthor> <ORCID/> <FirstName>Ezgi Turunc</FirstName> <LastName>Bayrakdar</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> <FirstName>Lutfiye Kan?t and Ayfer</FirstName> <LastName>Yalcin</LastName> <AuthorLanguage>English</AuthorLanguage> <Affiliation/> <CorrespondingAuthor>Y</CorrespondingAuthor> <ORCID/> </Author> </AuthorList> <DOI/> <Abstract>Kainic acid (KA)-induced neurotoxicity is mediated by oxidative stress, and melatonin (Mel), an antioxidant pineal hormone, provides neuroprotection against KA. The maintenance of intracellular redox homeostasis in brain is essential for neuronal survival and the regulation of redox homeostasis is provided by thiol containing molecules such as glutathione (GSH), thioredoxin (Trx)/thioredoxin reductase (TrxR) and redox factor-1 (Ref-1). In this study, we aimed to determine the effect of melatonin treatment on gene expressions of Trx, TrxR and Ref-1 against KA in rat hippocampus. Our results show that the levels of TrxR mRNA significantly increased in Mel+KA when compared to controls (p</Abstract> <AbstractLanguage>English</AbstractLanguage> <Keywords>kainic acid melatonin thioredoxin reductase redox factor-1 gene expression rat brain</Keywords> <URLs> <Abstract>https://aaspjournal.org/ubijournal-v1copy/journals/abstract.php?article_id=5912&title=Effect of melatonin co-treatment against kainic acid on thiol redox modulator gene expressions in Rat Hippocampus</Abstract> </URLs> <References> <ReferencesarticleTitle>References</ReferencesarticleTitle> <ReferencesfirstPage>16</ReferencesfirstPage> <ReferenceslastPage>19</ReferenceslastPage> <References/> </References> </Journal> </Article> </ArticleSet>