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<ArticleSet>
  <Article>
    <Journal>
      <PublisherName>aaspjournal</PublisherName>
      <JournalTitle>Journal of Asian Association of Schools of Pharmacy</JournalTitle>
      <PISSN>I</PISSN>
      <EISSN>S</EISSN>
      <Volume-Issue>Volume 15 Issue 1</Volume-Issue>
      <PartNumber/>
      <IssueTopic>Multidisciplinary</IssueTopic>
      <IssueLanguage>English</IssueLanguage>
      <Season>Jan - Dec 2026</Season>
      <SpecialIssue>N</SpecialIssue>
      <SupplementaryIssue>N</SupplementaryIssue>
      <IssueOA>Y</IssueOA>
      <PubDate>
        <Year>2026</Year>
        <Month>04</Month>
        <Day>10</Day>
      </PubDate>
      <ArticleType>Pharmacy</ArticleType>
      <ArticleTitle>Iontophoresis-assisted transdermal immunization induces anti-histone H1 antibody production and immunosuppressive activity</ArticleTitle>
      <SubTitle/>
      <ArticleLanguage>English</ArticleLanguage>
      <ArticleOA>Y</ArticleOA>
      <FirstPage>19</FirstPage>
      <LastPage>24</LastPage>
      <AuthorList>
        <Author>
          <FirstName>Takamitsu</FirstName>
          <LastName>Miyagi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>N</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Takeshi</FirstName>
          <LastName>Oshizaka*</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kenji</FirstName>
          <LastName>Mori</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Naoya</FirstName>
          <LastName>Ohmori</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Takeshi</FirstName>
          <LastName>Goto</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Shuji</FirstName>
          <LastName>Sato</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
          <FirstName>Kenji</FirstName>
          <LastName>Sugibayashi</LastName>
          <AuthorLanguage>English</AuthorLanguage>
          <Affiliation/>
          <CorrespondingAuthor>Y</CorrespondingAuthor>
          <ORCID/>
        </Author>
      </AuthorList>
      <DOI>https://doi.org/10.62100/jaasp.2026.15104</DOI>
      <Abstract>Most monoclonal antibodies and vaccines require injection by healthcare professionals. During the COVID-19 pandemic, vaccination programs faced delays due to shortages. Transdermal delivery has attracted interest to reduce workload. However, many vaccines and monoclonal antibodies show poor skin absorption due to high molecular weight, requiring permeation strategies. This study examined iontophoresis (IP), a method enhancing transdermal drug delivery, for vaccination. SSV-KLH, a peptide__ampersandsignndash;carrier conjugate vaccine designed to induce anti-histone H1 antibody production, was applied to mouse skin using IP. Immune responses were compared with intraperitoneal injection and transdermal delivery without IP. IP increased antibody production compared with non-IP delivery, although the difference was not significant. Antibody levels in the IP group were not significantly different from those in the intraperitoneal injection group. Both IP and injection induced similar immunosuppressive effects, unlike non-IP delivery. These results suggest IP enables effective transdermal vaccine delivery and may reduce reliance on healthcare professionals.</Abstract>
      <AbstractLanguage>English</AbstractLanguage>
      <Keywords>iontophoresis, vaccine, transdermal delivery, antibody production, immune response</Keywords>
      <URLs>
        <Abstract>https://aaspjournal.org/ubijournal-v1copy/journals/abstract.php?article_id=16202&amp;title=Iontophoresis-assisted transdermal immunization induces anti-histone H1 antibody production and immunosuppressive activity</Abstract>
      </URLs>
      <References>
        <ReferencesarticleTitle>References</ReferencesarticleTitle>
        <ReferencesfirstPage>16</ReferencesfirstPage>
        <ReferenceslastPage>19</ReferenceslastPage>
        <References/>
      </References>
    </Journal>
  </Article>
</ArticleSet>