ISSN 2286-6493
Journal of Asian Association of Schools of Pharmacy

In vitro uterine relaxant activity of Fire Ha Kong Recipe in rats  Research Paper 

Penchom Peungvicha1*, Yuvadee Wongkrajang1, Boontium Kongsaktrakoon1, Kanjana Jittiporn2 and Somsak Nualkaew3
1 Department of Physiology, Faculty of Pharmacy, Mahidol University, Bangkok 10400, Thailand.
2 Department of Cardio-thoracic Technology, Faculty of Allied Health Sciences, Naresuan University, Thailand.
3 Pharmaceutical Chemistry and Natural Product Research Unit, Faculty of Pharmacy, Mahasarakham University, Kantarawichai, Mahasarakham, 44150, Thailand.


    Fire Ha Kong recipe in a concentration range of 1040 µl/ml was used to test in an in vitro uterine contraction inhibition. Contraction frequencies and amplitudes of the normal uterine of estrogen-primed non-pregnant rats were monitored. A decline in the frequencies of uterine contractions of 43.8 - 93.6% was detected. Addition of Fire Ha Kong at the final concentrations of 20-40 µl/ml inhibited the amplitudes of uterus contraction by 57.1% and 85.7%, respectively. The reductions in area under the curve (AUC) of contractions were 57.1% and 85.7% for the added concentrations. Fire Ha Kong recipe revealed inhibitory effects on the uterine response to oxytocin (10-11 M) 31.9% and 29.3% only in frequency but not in amplitude and AUC in comparison to oxytocin alone. These results indicate that the tocolytic potential of Fire Ha Kong recipe may involve oxytocin receptor-dependent pathway or reduce the intracellular availability of calcium ions.  


1 Fire Ha Kong recipe
2 uterine contractions
3 in vitro test
4 rat
5 oxytocin

Published in

JAASP Volume 3
January - December, 2014

Page: 299-305

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