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Liposomes: A novel carrier system for Artocarpus lakoocha extract to improve skin whitening
Veerawat Teeranachaideekul, Saruth Nithitanakool, Tipwimol Junhunkit, Lakkhana Ponpanich, Nisa Nopporn, Usanee Detamornrat, and Malyn Chulasiri
The results of the conducted studies showed that the hydroglycolic extract of Artocarpus lakoocha (AL) heartwood exhibited the potent antioxidant and tyrosinase inhibitory activities compared with positive references which are commonly used as antioxidant and skin-whitening agents in cosmetic products. Encapsulation of AL heartwood extract into liposomes can provide prolonged release. Based on the in vitro skin permeation study using a synthetic membrane made from two layers of polyethersulfone (PES) on top of a layer of polyolefine as a skin model, the cumulative amount per area of AL heartwood extract-encapsulated liposomes was higher than that of non-encapsulated one. In addition, in vivo skin whitening study showed that the lotion containing AL heart-wood extract-loaded liposomes exhibited better skin whitening effect on human volunteers than the lotion containing non-encapsulated AL heartwood extract. The obtained results show that liposomes are a promising delivery system for enhancing skin delivery of AL heartwood extract effectively.
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Other in Vol. 2
Values of leftover drugs in households: preliminary study in 5 major Thai cities
Liposomes: A novel carrier system for Artocarpus lakoocha extract to improve skin whitening
Screening of antioxidant activity of vegetables in Thailand
Preliminary study of the applications of Ganoderma lucidum in chronic fatigue syndrome
Iron chelating activity of Pyoverdin PaII and pseudobactin 589 siderophores with plasma iron

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