The Official Journal of Asian Association of Schools of Pharmacy
 
 Search JAASP  
JAASP Home
Journal Information
Back Issues
Author Guidelines
Manuscript Submission
Advertisement
Publications
Contact JAASP
AASP Official Website
 


 
Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats
Saowaluk Sawangdee, Yuvadee Wongkrajang, Suchitra Thongpraditchote, Penchom Peungvicha, Boonthium Kongsaktrakoon and Chuthamanee Suthisisang
Phenylpropanolamine (PPA) is a sympathomimetic drug that exerts its effect mainly through the alphaadrenergic receptor. A pharmacoepidemiological study reported by the hemorrhagic stroke project in the year 2000 suggested an association between high dose PPA and hemorrhagic stroke. However, the hemodynamic effect of PPA might be altered in the presence of chlorpheniramine (CPM) as used in over-the-counter cold remedy (PPA, 0.3 mg/kg plus CPM, 0.04 mg/kg). It was found that PPA (5-30 times that used in humans) dose-dependently increased in blood pressure in rats and this effect was antagonized by CPM in male rats and non-proestrous female rats but not in proestrous female rats. The hypertensive effect of PPA could not be antagonized by loratadine, a highly specific H1 blocker.
Download Full Paper (PDF 803.32 KB.)



Other in Vol. 1 No. 4
Cancer cachexia and metabolism:a challenge in nutrition oncology
How to help first-year pharmacy students to gain the big picture
Fabrication of calcium pectinate microparticles from pomelo pectin by ionotropic gelation
Isoindole-1,3-dione-based a,?-diketo acid bioisosteres as hepatitis C virus NS5B polymerase inhibitors
Chlorpheniramine attenuated hypertensive effect of phenylpropanolamine in rats
 
 


 
  Sign in
Please sign in to submit or edit your manuscripts
Username
Password
No account? Please Sign up
   
 

 

 
You are visitor number 206612. since June 2012