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Neuritogenic and antioxidant activities of nordentatin from Clausena harmandiana
Pongsakorn Jantakoon, Sarin Tadtong and Ploenthip Puthongking
Nordentatin, a member of coumarins from natural sources, was identified from root bark of Clausena harmandiana and previously tested by 1,1-diphenyl-2- pricrylhydrazyl (DPPH) and thiobarbituric acid reactive substances (TBARS) indicating its potent antioxidant and inhibition of lipid peroxidation. This lead to further isolate of its derivatives, dentatin and xanthoxyletin, and evaluate their activities on neuritogenic and neurotoxic using cultured P19 neurons and antioxidant effects. Nordentatin showed no neurotoxicity on the cultured cells (IC50>10 M) while dentatin and xanthoxyletin expressed neurotoxicity at 1 nM (viability 62.28 12.11% and 43.0210.31%, respectively). Phasecontrast micrographs showed that nordentatin promoted neurites outgrowth of the neurons. The neurons treated with nordentatin displayed significantly more branching numbers of the neurites than the control (p < 0.05). It can be concluded that nordentatin is a remarkable neuritogen from natural product.
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Other in Vol. 1 No. 3
Pharmacy practice in Singapore and training experiences in the United States
Unit cost of diabetes screening in community pharmacy
Stability of trace elements and vitamin-containing TPN admixture of in a multi-chamber bag (Fulcaliq)
Analgesic, anti-inflammatory, antipyretic activities and acute toxicity of the ethanolic extract of Clausena harmandiana Pierre in animals
Regulatory issues on traditionally used herbal products, herbal medicines and food supplements in the Philippines
Neuritogenic and antioxidant activities of nordentatin from Clausena harmandiana

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