The Official Journal of Asian Association of Schools of Pharmacy
 
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Analgesic, anti-inflammatory, antipyretic activities and acute toxicity of the ethanolic extract of Clausena harmandiana Pierre in animals
Jinda Wangboonskul, Auemduan Prawan, Pobporn Takthaisong, Watikan Sasithornwetchakun, Chantana Boonyarat, Chavi Yenjai and Pramote Mahakunakorn

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Clausena harmandiana Pierre (CH), a local plant used traditionally for pain relief and antipyretic, was used to investigate analgesic, anti-inflammatory, antipyretic activities and acute toxicity from an ethanolic extract of its root bark (CH-EtOH). Chemical analysis by HPLC indicated dentatin and nordentatin contents in CH-EtOH at 1.71 and 2.57% w/w, respectively. Analgesic activity of oral CH-EtOH was tested in mice by thermal threshold tests and acetic acid (AA)-induced writhing response, antiinflammatory by carrageenan-induced rat paw edema, antipyretic by baker yeast-induced fever rat model and acute toxicity followed OECD Guidelines. Oral CH-EtOH significantly decreased writhing responses in a dose-dependent manner (p<0.05), but slightly affected thermal thres-hold, suggesting its peripheral analgesic action. It showed no antiinflammatory activity but significantly reduced the rectal temperature on yeast-induced pyrexia (p<0.05) in a dose-dependent manner comparable to paracetamol. Acute toxicity test of oral CH-EtOH up to 3 g/kg did not show any serious toxic effects during a 7-day period of observations. This evidenced the use of ethanolic extract of root bark of C. harmandiana in folk medicine as analgesic and antipyretic agents.
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Other in Vol. 1 No. 3
Pharmacy practice in Singapore and training experiences in the United States
Unit cost of diabetes screening in community pharmacy
Stability of trace elements and vitamin-containing TPN admixture of in a multi-chamber bag (Fulcaliq)
Analgesic, anti-inflammatory, antipyretic activities and acute toxicity of the ethanolic extract of Clausena harmandiana Pierre in animals
Regulatory issues on traditionally used herbal products, herbal medicines and food supplements in the Philippines
Neuritogenic and antioxidant activities of nordentatin from Clausena harmandiana
 
 


 
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