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Stability of trace elements and vitamin-containing TPN admixture of in a multi-chamber bag (Fulcaliq)
Yuko Okuyama, Takeshi Akiyoshi, Toru Asayama, Masami Hirai, Kenji Matsuyama and Hisakazu Ohtani
A multi-chamber for total parenteral nutrition (TPN), Fulcaliq®, which is convenient for mixing of liquids from 3 chambers, was stability evaluated in clinical setting when exposed to trace elements up to 14 days. Branded or generic formulations of trace elements were compared in 3 groups: 1) glucose solution + trace elements, 2) a mixture of glucose solution and amino acid solution (Mixture A) + trace elements and 3) the 3 solutions (Mixture B) + trace elements. Stability was assessed visually and by means of pH measurement and UV-vis spectrophotometry. In all samples, no suspension or particles were visually identified and the pH remained within the controlled range of Fulcaliq itself. With regard to the color and absorbance, the glucose solution spiked with trace elements remained unchanged up to Day 14, Mixture A and Mixture B spiked with trace elements started to change from Day 7. The same results were observed upon spiking with a generic drug instead of a branded one as trace elements. For the glucose solution spiked with trace elements, unless not mixed with other solution(s), it is not crucial to mix the trace elements just before use, and it can be prepared and supplied weekly.
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Other in Vol. 1 No. 3
Pharmacy practice in Singapore and training experiences in the United States
Unit cost of diabetes screening in community pharmacy
Stability of trace elements and vitamin-containing TPN admixture of in a multi-chamber bag (Fulcaliq)
Analgesic, anti-inflammatory, antipyretic activities and acute toxicity of the ethanolic extract of Clausena harmandiana Pierre in animals
Regulatory issues on traditionally used herbal products, herbal medicines and food supplements in the Philippines
Neuritogenic and antioxidant activities of nordentatin from Clausena harmandiana

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