The Official Journal of Asian Association of Schools of Pharmacy
 
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Solid state characterization of trans resveratrol complexes with different cyclodextrins
Mont Kumpugdee-Vollrath, Yvonne Ibold and Pornsak Sriamornsa
Trans resveratrol (Res) has been investigated numerously because of having interesting pharmacological effects but Res has low bioavailability. As the solubility, stability and bioavailability of a drug can be increased by a complexation with cyclodextrin (CD), it was herein to prepare ResCD complexes and their physical mixtures different types of CD. In order to understand the solid state behavior, various characterization techniques were applied. The results from differential scanning calorimetry showed double peaks at 254C and 269C, demonstrating the melting point of pure Res. Most of the pure CDs decomposed over 300C. Beta-CD and 2- hydroxypropyl-beta-CD had a significant peak around 100C which demonstrated the evaporation of water. Alpha-CD had many peaks between 80-140C and also 269C which differed from dimethyl-beta-CD. Res alpha-CD complex showed peaks at 130C and 269C, whereas Resbeta-CD only showed peak at 269C. The modified CDs did not show the significant peak of Res or water. This indicated that Res replaced water in the cavity and a real inclusion complex was formed. The infrared spectra also confirmed the formation of complex. The small and wide angle X-ray scattering patterns showed the difference of Res, CD and different complexes.
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Other in Vol. 1 No. 2
Pharmacy education experience in the U.S.A.- implications for Asia
Academic achievement of Thai pharmacy students in an Englishtaught program
Issues and concerns on utilization of the pharmacy workforce in the Philippines
Assessment of mutagenic and genotoxic activity of Caesalpinia sappan L. extract by Ames test and micronucleus assay
Genotoxicity assessment of recombinant human interferon gamma in human lymphocytes
Effect of fibroin gel from Thai silk cocoon on color extract of Rosa spp. flowers
Solid state characterization of trans resveratrol complexes with different cyclodextrins
 
 


 
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