The Official Journal of Asian Association of Schools of Pharmacy
 
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Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes
Worawan Kitphati, Kittima Wattanakamolkul, Pattamapan Lomarat, Phanida Phanthong, Natthinee Anantachoke, Veena Nukoolkarn, Krit Thirapanmethee, Nuntav
Essential oils have the strong potency to inhibit acetylcholinesterase (AChE) in brain because of their lipophilicity and small molecular size constituents. The anticho-linesterase activity of 13 essential oils from Thai medicinal plants was primarily evaluated using purified AChE from eel. Results revealed 6 of them including those from turmeric, galangal, fingerroot, plai, betel vine and holy basil showed such activity. However, only essential oils from turmeric, galangal and fingerroot exhibited the appreciable effects. Their constituents were then identified and also investigated for AChE inhibitory activity. Results revealed a number of constituents were found but their effect on anticho-linesterase activity was not impressive as their originated oils either in single or combination. When turmeric, galangal and fingerroot oils were tested in neuroblastoma SK-N-SH cells, they showed the appreciable potentials in inhibiting cellular AChE of these cells as well.
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Other in Vol. 1 No. 1
Preparing pharmacists through pharmacy education and training for a professional role serving their communities
Centennial pharmacy education in Thailand
Prevalence, perceptions and predictors of complementary and alternative medicine use in selected communities in the Philippines
Comparison of incidences of diabetes and hypertension in primary care units
An intravenous injection of melatonin: formulation, stability, pharmacokinetics and pharmacodynamics
Effect of melatonin co-treatment against kainic acid on thiol redox modulator gene expressions in rat Hippocampus
Comparison of nitrate content in soils of vegetable farms in Tehran
Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes
 
 


 
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