The Official Journal of Asian Association of Schools of Pharmacy
 
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Effect of melatonin co-treatment against kainic acid on thiol redox modulator gene expressions in rat Hippocampus
Guliz Armagan, Ezgi Turunc Bayrakdar, Lutfiye Kanıt and Ayfer Yalcin
Kainic acid (KA)-induced neurotoxicity is mediated by oxidative stress, and melatonin (Mel), an antioxidant pineal hormone, provides neuroprotection against KA. The maintenance of intracellular redox homeostasis in brain is essential for neuronal survival and the regulation of redox homeostasis is provided by thiol containing molecules such as glutathione (GSH), thioredoxin (Trx)/thioredoxin reductase (TrxR) and redox factor-1 (Ref-1). In this study, we aimed to determine the effect of melatonin treatment on gene expressions of Trx, TrxR and Ref-1 against KA in rat hippocampus. Our results show that the levels of TrxR mRNA significantly increased in Mel+KA when compared to controls (p<0.01) and Mel only (p<0.05). The Mel only treatment significantly decreased the expression of Ref-1 mRNA. Also, there was a significant difference in the expression of Ref-1 mRNA between Mel+KA and Mel only (p<0.01). However, there was no significant change in the expressional levels of Trx mRNA in Mel- and Mel+KA-treated rats. Our results may suggest that melatonin plays a role in the regulation of thiol redox modulator genes in the brain in order to maintain cellular redox homeostasis against KA-induced oxidative stress.
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Other in Vol. 1 No. 1
Preparing pharmacists through pharmacy education and training for a professional role serving their communities
Centennial pharmacy education in Thailand
Prevalence, perceptions and predictors of complementary and alternative medicine use in selected communities in the Philippines
Comparison of incidences of diabetes and hypertension in primary care units
An intravenous injection of melatonin: formulation, stability, pharmacokinetics and pharmacodynamics
Effect of melatonin co-treatment against kainic acid on thiol redox modulator gene expressions in rat Hippocampus
Comparison of nitrate content in soils of vegetable farms in Tehran
Anticholinesterase of essential oils and their constituents from Thai medicinal plants on purified and cellular enzymes
 
 


 
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